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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13419 | ROCK-IN-1 | ROCK | |
ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological disorders and inflammation-related diseases. | |||
TQ0110 | ROCK-IN-2 | TC-S 7001,Azaindole 1 | ROCK |
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2. | |||
T24723 | ROCK-IN-D1 | ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1 | |
ROCK-IN-D1 is an effective and selective inhibitor of ROCK. | |||
T79905 | Akt/ROCK-IN-1 | ROCK | |
Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively. It possesses antitumor efficacy against neuroblastoma [1]. | |||
T12721 | Rho-Kinase-IN-1 | ROCK | |
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise... | |||
T9652 | SB-747651A Dihydrochloride | ROCK | |
SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibit... | |||
T4S1962 | Beta-Asarone | Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin | NF-κB , JNK |
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be... | |||
T5S0053 | Coptisine | Coptisin | Indoleamine 2,3-Dioxygenase (IDO) |
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ... | |||
T79080 | ROCK-IN-7 | ROCK | |
ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1]. | |||
T79809 | ROCK-IN-8 | ROCK | |
ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research, demonstrating an IC50 value below 100 nM [1]. | |||
T79833 | ROCK-IN-9 | ROCK | |
ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM. It demonstrates favorable pharmacokinetic properties in mice, achieving high in vivo exposure and oral bioavailab... | |||
T79832 | ROCK2-IN-6 | ROCK | |
ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1]. | |||
T79077 | ROCK-IN-6 | ROCK | |
ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1]. | |||
T78205 | ROCK2-IN-6 hydrochloride | ROCK | |
ROCK2-IN-6 hydrochloride (Comp A) serves as a selective inhibitor of ROCK2, applicable for research into ROCK-mediated diseases, autoimmune disorders, and inflammation [1]. | |||
T61497 | Rho-Kinase-IN-2 | ||
Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC5... | |||
T69429 | Y27632 HCl hydrate | ||
Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepa... | |||
T35659 | 3'-Dephosphocoenzyme A | ||
3'-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A from pantothenic acid .1 It is phosphorylated by CoA synthase in humans to form CoA. 3'-Dephosphocoenzyme A can be used as a transcription initi... | |||
T37847 | Zonisamide-13C2,15N | Zonisamide-13C2,15N | |
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels ... |